After looking into NodeJs yesterday, I now feel the urge to check out the frameworks available for NodeJs.
A great resource for comparing NodeJs frameworks is nodeframework.com. You can choose between MVC, full stack, REST API and others.
I was interested in the full stack ones, and the one that first caught my eye was meteor with their great screencast. They also seem to be the ones with the most active development, so I guess I will look further into this one.